“Brain diseases, including neurodegenerative diseases and neuropsychiatric disorders, have been a major public health problem.
There is no drug that can completely reverse the progression without side effects, whereas PBMT has been demonstrated to be capable of delaying the progression of disability, promoting brain function recovery, and reducing the frequency of relapses.”
“Recent advances in photobiomodulation therapy for brain diseases”
Journal: Interdisciplinary Medicine, 2024
Laser interstitial thermal therapy (LiTT) is a minimally invasive alternative to conventional open surgery for drug-resistant focal mesial temporal lobe epilepsy (MTLE). Recent studies suggest that higher seizure freedom rates are correlated with maximal ablation of the amygdala-hippocampal complex (AHC), whilst sparing of the parahippocampal gyrus (PHG) may reduce neuropsychological sequelae
“Low-level laser therapy leads to a reduction in inflammatory immune cells, including TH1 and TH17, inhibits inflammation, and augments brain tissue regeneration.”
The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study
Journal: Journal of Lasers in Medical Sciences, 2021
“Patients saw benefit often within four treatments and resolution of depressive symptoms occurred within 4 weeks for some.”
Muti-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study
Journal: Frontiers in Psychiatry, 2017
“PBMT can be classified as strongly recommended for moderate grade of major depressive disorder (MDD) and recommended for anxiety disorder.”
Photobiomodulation therapy in mood disorders: a systematic review
Journal: Lasers in Medical Science, 2022
“This systematic review clearly demonstrates the therapeutic role of PBM combined therapies, as well as their potential to improve treatment efficacy and reduce side effects across a wide range of central and peripheral neurological disorders.”
Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review
Journal: BMC Neurology, 2024
“Near-infrared II photobiomodulation could offer a noninvasive and low-risk adjunctive therapy for stroke injury.”
Near-Infrared II Photobiomodulation Preconditioning Ameliorates Stroke Injury via Phosphorylation of eNOS
Journal: Stroke, 2024 (American Heart Association)
“Infrared photobiomodulation embodies a remarkable and powerful tool for influencing mitochondrial function, inflammation, perfusion, and tissue repair mechanisms in the brain and other tissues.”
Can infrared light really be doing what we claim it is doing? Infrared light penetration principles, practices, and limitations
Journal: Frontiers in Neurology, 2024
“There was significant improvement after 12 weeks of PBM. Increased function, better sleep, fewer angry outbursts, less anxiety, and wandering were reported post-PBM. There were no negative side effects.”
Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
Journal: Photomedicine and Laser Surgery, 2017
“PBM has shown potential to halt or even reverse the progression of AD, as evidenced by improvements in cognitive impairment and memory across various published studies.”
Modifying Alzheimer’s disease pathophysiology with photobiomodulation: model, evidence, and future with EEG-guided intervention
Journal: Frontiers in Neurology, 2024
“Simultaneous intranasal and transcranial PBM (itPBM) is emerging as a possible treatment for cognitive and psychological sequelae of brain injury with evidence of remote effects on other body systems.”
The Effect of Intranasal Plus Transcranial Photobiomodulation on Neuromuscular Control in Individuals with Repetitive Head Acceleration Events
Journal: Photobiomodulation, Photomedicine, and Laser Surgery, 2024
“A total of eleven randomized controlled trials was included in this meta-analysis, and the combined data suggest that PBM may be an efficacious depression treatment.”
Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials
Journal: Frontiers in Psychiatry, 2024
“Transcranial photobiomodulation has demonstrated its value as a treatment for neurological and neurodegenerative conditions, including Alzheimer’s disease.”
Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study.
Journal: Scientific Reports, 2019
“Transcranial photobiomodulation may help the brain switch from a state of mind-wandering (DMN) to a state of focused attention (salience and central executive networks) more readily.”
Enhancement of Divergent Creative Thinking After Transcranial Near-Infrared Photobiomodulation Over the Default Mode Network
Journal: Creativity Research Journal, 2024